"If you're a healthy human when you're 20, 30, or 40, you really don't have a lot of senescent cells, it appears," Robbins said. In aging mice, when these zombie cells are wiped out, functionality of key organs like the heart, liver, lungs, and the brain all improve, as systemic inflammation goes down. The National Institutes of Health is so concerned about senescent cells' impact on aging they're funding $125 million in grants to study them over the next few years. Yet they can still release molecules that trigger inflammation. These cells are also called "zombie cells" because they have stopped multiplying, but don't die off. Scientists call fisetin a "senolytic" because it targets and wipes out senescent cells in the body, which build up as people age and contribute to age-related health issues. Liao Pan/China News Service via Getty Images People shop for fruits at the Union Square Farmers Market on Jin New York City. He says it's entirely possible that everything he's feeling could just be a powerful placebo effect. Is that real? Who knows," Robbins told Insider. "I have a knee that's kind of cranky - it always seems to feel better right after I take it. He has already shown in published research that fisetin, which is also found in other red and rust-colored fruits like apples and persimmons, can extend and improve the lives of lab mice.īut during the pandemic he started to wonder: What if fisetin could help him age better, and improve his immunity, by reducing inflammation, and lowering the levels of potent "zombie" cells building up in his body over time? He started taking a dose of fisetin once every two weeks, hoping it might help boost his immunity - and he hasn't stopped since. Paul Robbins, co-director of the Institute of the Biology of Aging and Metabolism at the University of Minnesota, has been studying fisetin for years, and he's been impressed at how it can help lab mice stay healthy. It turns out that a single, special compound found in strawberries, called fisetin, is a zombie cell killer. The same chemicals that give bright red strawberries their vibrant taste and color might also be a secret ingredient to healthy aging.
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